Notice my mouse looks weird? This happens in game too, its really annoying!

and in the colors, the mice's eyes are lower and they look like they have down syndrome

Right click Transformice, uncheck "Select All, relog.

How I fix this issue of Low Quality, just click the "Forums" button and then close the forums you should be back to normal

I think so

This also has happened to me and i suggest you to try this:
Click this:


Then press 'zoom in fullscreen' twice
It worked for me. If it does not work, dont blame me.