Mr. Osomatsu is based off of the gag manga series Osomatsu-kun by Fujio Akatsuka, and ran from 1962 to 1969. The series features a set of sextuplets, the Matsuno brothers, with Osomatsu being the oldest brother and leader of the group. (Description from Crunchyroll)

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Osomatsu-kun (おそ松くん?) is a comedy manga series by Fujio Akatsuka which ran in Shogakukan's Weekly Shōnen Sunday magazine from 1962 to 1969. The series revolves around a group of sextuplet brothers who cause all sorts of mischief. It has been adapted into two different anime series of the same name, the first in 1966, produced by Studio Zero, and the second in 1988, produced by Pierrot and aired across Japan on Fuji Television, the anime satellite television network, Animax, and the South Korean kids channel, Cartoon Network Korea. A new anime series by Studio Pierrot, Osomatsu-san (おそ松さん?), began airing in October 2015 to celebrate Akatsuka's 80th birthday, with a manga adaptation by Masako Shitara serialized in Shueisha's You magazine from January 2016.

This series helped establish Akatsuka's reputation as a gag comic artist, long before his other popular manga, Tensai Bakabon. Osomatsu-kun has appeared in numerous special issues of Shōnen Sunday. Akatsuka has also included several manga adaptations of routines from Charlie Chaplin movies in the series.

In 1964, Akatsuka won the 10th Shogakukan Manga Award for Osomatsu-kun.

Osomatsu-san (おそ松さん?), produced by Pierrot, began airing from October 5, 2015 and is being simulcast by Crunchyroll, making it the first piece of Osomatsu-kun media to receive an official English release. The series, which celebrates the 80th birthday of creator Fujio Akatsuka, who died at the age of 72 in 2008, follows the Matsuno siblings as adults. (Wikipedia)


Please watch Osomatsu-san.

Crunchyroll (Watch here, legally)
Wikipedia for the series.
Myanimelist page for Osomatsu-san.
Official site for Osomatsu-san.
Official Twitter for Osomatsu-san. (You can find teasers here!)